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Molecular signaling network and therapeutic developments in breast cancer brain metastasis
- Source :
- Advances in Cancer Biology - Metastasis, Vol 7, Iss , Pp 100079- (2023)
- Publication Year :
- 2023
- Publisher :
- Elsevier, 2023.
-
Abstract
- Breast cancer (BC) is one of the most frequently diagnosed cancers in women worldwide. It has surpassed lung cancer as the leading cause of cancer-related death. Breast cancer brain metastasis (BCBM) is becoming a major clinical concern that is commonly associated with ER-ve and HER2+ve subtypes of BC patients. Metastatic lesions in the brain originate when the cancer cells detach from a primary breast tumor and establish metastatic lesions and infiltrate near and distant organs via systemic blood circulation by traversing the BBB. The colonization of BC cells in the brain involves a complex interplay in the tumor microenvironment (TME), metastatic cells, and brain cells like endothelial cells, microglia, and astrocytes. BCBM is a significant cause of morbidity and mortality and presents a challenge to developing successful cancer therapy. In this review, we discuss the molecular mechanism of BCBM and novel therapeutic strategies for patients with brain metastatic BC.
Details
- Language :
- English
- ISSN :
- 26673940
- Volume :
- 7
- Issue :
- 100079-
- Database :
- Directory of Open Access Journals
- Journal :
- Advances in Cancer Biology - Metastasis
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.055df6986ea94b5bb42e60ef1f6e5db7
- Document Type :
- article
- Full Text :
- https://doi.org/10.1016/j.adcanc.2022.100079