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Adaptive translational reprogramming of metabolism limits the response to targeted therapy in BRAFV600 melanoma
- Source :
- Nature Communications, Vol 13, Iss 1, Pp 1-21 (2022)
- Publication Year :
- 2022
- Publisher :
- Nature Portfolio, 2022.
-
Abstract
- Different adaptive mechanisms have been reported to reduce the efficacy of mutant BRAF inhibition in melanoma. Here, the authors show BRAF inhibition induces the translational regulation of metabolic genes leading to acquired therapy resistance.
- Subjects :
- Science
Subjects
Details
- Language :
- English
- ISSN :
- 20411723
- Volume :
- 13
- Issue :
- 1
- Database :
- Directory of Open Access Journals
- Journal :
- Nature Communications
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.059612c027f74f17b5f4fdc038786683
- Document Type :
- article
- Full Text :
- https://doi.org/10.1038/s41467-022-28705-x