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Citrullination of glucokinase is linked to autoimmune diabetes

Authors :
Mei-Ling Yang
Sheryl Horstman
Renelle Gee
Perrin Guyer
TuKiet T. Lam
Jean Kanyo
Ana L. Perdigoto
Cate Speake
Carla J. Greenbaum
Aïsha Callebaut
Lut Overbergh
Richard G. Kibbey
Kevan C. Herold
Eddie A. James
Mark J. Mamula
Source :
Nature Communications, Vol 13, Iss 1, Pp 1-11 (2022)
Publication Year :
2022
Publisher :
Nature Portfolio, 2022.

Abstract

Post translational modifications are involved in the regulation of a number of proteins and can be themselves modified by the cellular environment. Here the authors implicate citrullination of glucokinase in autoimmune diabetes

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723
Volume :
13
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.05c25682e0244aef9cf1385fd566a122
Document Type :
article
Full Text :
https://doi.org/10.1038/s41467-022-29512-0