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Tourniquets can further reduce perioperative blood loss in patients on dexamethasone and tranexamic acid during cemented total knee arthritis: a single-center, double-blind, randomized controlled trial

Authors :
Wenyu Jiang
Xing Wang
Hong Xu
Menghan Liu
Jinwei Xie
Qiang Huang
Ronghua Zhou
Zongke Zhou
Fuxing Pei
Source :
Journal of Orthopaedics and Traumatology, Vol 24, Iss 1, Pp 1-10 (2023)
Publication Year :
2023
Publisher :
SpringerOpen, 2023.

Abstract

Abstract Background Multiple doses of dexamethasone and tranexamic acid can inhibit postoperative inflammation and reduce fibrinolysis and perioperative blood loss in total knee arthroplasty. In this single-center, double-blind, randomized clinical trial, the aim was to investigate whether applying a tourniquet to patients on dexamethasone and tranexamic acid could further reduce perioperative blood loss. Materials and methods Patients who underwent cemented total knee arthroplasty at our hospital were randomized to receive a tourniquet (n = 71) or not (n = 70) during the procedure. All patients received multiple doses of dexamethasone and tranexamic acid perioperatively. The primary outcome was perioperative blood loss, while secondary outcomes were surgery duration, postoperative laboratory indices of inflammation and fibrinolysis, range of knee motion, VAS pain score, knee circumference, knee swelling rate, homologous transfusion, albumin use, and complications. Results Using a tourniquet was associated with significantly lower intraoperative blood loss (P

Details

Language :
English
ISSN :
15909999
Volume :
24
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Journal of Orthopaedics and Traumatology
Publication Type :
Academic Journal
Accession number :
edsdoj.0653f73aaae048f88ec4f67fd36fb099
Document Type :
article
Full Text :
https://doi.org/10.1186/s10195-023-00698-3