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In situ magnesium calcium phosphate cements formation: From one pot powders precursors synthesis to in vitro investigations
- Source :
- Bioactive Materials, Vol 5, Iss 3, Pp 644-658 (2020)
- Publication Year :
- 2020
- Publisher :
- KeAi Communications Co., Ltd., 2020.
-
Abstract
- Calcium phosphate cements are of great interest for researchers and their applications in medical practice expanded. Nevertheless, they have a number of drawbacks including the insufficient level of mechanical properties and low degradation rate. Struvite (MgNH4PO4) -based cements, which grew in popularity in recent years, despite their neutral pH and acceptable mechanical performance, release undesirable NH4+ ions during their resorption. This issue could be avoided by replacement of ammonia ions in the cement liquid with sodium, however, such cements have a pH values of 9–10, leading to cytotoxicity.Thus, the main goal of this investigation is to optimize the composition of cements to achieve the combination of desirable properties: neutral pH, sufficient mechanical properties, and the absence of cytotoxicity, applying Na2HPO4-based cement liquid. For this purpose, cement powders precursors in the CaO–MgO–P2O5 system were synthesized by one-pot process in a wide composition range, and their properties were investigated.The optimal performance was observed for the cements with (Ca + Mg)/P ratio of 1.67, which are characterized by newberyite phase formation during setting reaction, pH values close to 7, sufficient compressive strength up to 22 ± 3 MPa (for 20 mol.% of Mg), dense microstructure and adequate matrix properties of the surface. This set of features make those materials promising candidates for medical applications.
Details
- Language :
- English
- ISSN :
- 2452199X
- Volume :
- 5
- Issue :
- 3
- Database :
- Directory of Open Access Journals
- Journal :
- Bioactive Materials
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.06c99fb681e849f3930a8729f0c56362
- Document Type :
- article
- Full Text :
- https://doi.org/10.1016/j.bioactmat.2020.03.011