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Peroxisome proliferator-activated receptors gama ameliorates liver fibrosis in non-alcoholic fatty liver disease by inhibiting TGF-β/Smad signaling activation

Peroxisome proliferator-activated receptors gama ameliorates liver fibrosis in non-alcoholic fatty liver disease by inhibiting TGF-β/Smad signaling activation

Authors :
Zhang Qingwei
Zhao Wenjie
Sun Zeqi
Dong Xinxin
Zhu Liwei
Zhang Zhen
Chen Ximing
Hu Yingying
Du Menghan
Li Jiamin
Zhang Yong
Source :
Frigid Zone Medicine, Vol 4, Iss 1, Pp 12-22 (2024)
Publication Year :
2024
Publisher :
De Gruyter, 2024.

Abstract

Nonalcoholic fatty liver disease (NAFLD) is a chronic condition characterized by a progressive decline in liver function, leading to disruptions in liver integrity and metabolic function, resulting in lipid deposition and excessive accumulation of extracellular matrix (ECM). The pathogenesis of NAFLD is complex and not yet fully understood, contributing to the absence of specific therapeutic strategies. Peroxisome proliferator-activated receptor gamma (PPARγ) is a ligand-activated transcription factor pivotal in regulating lipid and glucose metabolism. However, the impacts of PPARγ on NAFLD remains insufficiently explored. Thus, this study aimed to investigate the role of PPARγ in NAFLD and its underlying molecular mechanisms.

Details

Language :
English
ISSN :
27198073
Volume :
4
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Frigid Zone Medicine
Publication Type :
Academic Journal
Accession number :
edsdoj.07502db883647b88d2801ed09eba457
Document Type :
article
Full Text :
https://doi.org/10.2478/fzm-2024-0002