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Management of oral submucous fibrosis by two different drug regimens: A comparative study
- Source :
- Dental Research Journal, Vol 10, Iss 4, Pp 527-532 (2013)
- Publication Year :
- 2013
- Publisher :
- Wolters Kluwer Medknow Publications, 2013.
-
Abstract
- Background: Oral Submucous Fibrosis (OSF) is a precancerous condition of the oral mucosa. Existing treatments give only temporary symptomatic relief. Colchicine is an ancient drug with anti-fibrotic and anti-inflammatory properties. We planned to study the effects of colchicine in the management of oral submucous fibrosis. Materials and Methods: Fifty OSF patients were divided randomly into two groups and treated for 12 weeks. Group 1-Patients were administered tablet colchicine orally, 0.5 mg twice daily and 0.5 ml intralesional injection Hyaluronidase 1,500 IU into each buccal mucosa once a week. Group 2-Patients were administered 0.5 ml intralesional injection Hyaluronidase 1,500 IU and 0.5 ml intralesional injection Hydrocortisone acetate 25 mg/ml in each buccal mucosa once a week alternatively. Student′s t test and analysis of variance (ANOVA) were used to compare pre and post treatment results. P
Details
- Language :
- English
- ISSN :
- 17353327 and 20080255
- Volume :
- 10
- Issue :
- 4
- Database :
- Directory of Open Access Journals
- Journal :
- Dental Research Journal
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.07bb358542ac84a7bb86b7130454
- Document Type :
- article
- Full Text :
- https://doi.org/10.4103/1735-3327.118481