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Study on the Growth and Regulation of Large-Particle Sr(OH)2·8H2O Crystals with Process Analytical Technology

Authors :
Binbin Shi
Yongjuan Zhang
Shudong Liang
Yanan Wang
Yan Jing
Xingwu Zou
Xuezhong Wang
Source :
Crystals, Vol 14, Iss 1, p 4 (2023)
Publication Year :
2023
Publisher :
MDPI AG, 2023.

Abstract

Sr(OH)2 is an indispensable strontium compound extensively harnessed in sugar refining, strontium lubricating wax formulation, and polymer plastic stabilization. Sr(OH)2·8H2O is the prevalent hydrate form of Sr(OH)2. Deprived of moisture via vacuum drying, Sr(OH)2 can be procured from Sr(OH)2·8H2O. Sr(OH)2·8H2O particles with larger sizes exhibit impressive attributes such as facile solid–liquid divergence, elevated product purity, expedient drying, and resilience to agglomeration, which have garnered significant interest. Given the superior quality of the product and the dependability of the process, process analytical technology (PAT) has been extensively employed in the pharmaceutical sector, rendering it feasible to employ PAT to fabricate large-particle Sr(OH)2·8H2O crystals. This study utilizes industrial SrCO3 to prepare high-purity Sr(OH)2·8H2O with a purity of over 99.5%. The growth process of single crystals was observed using a hot-stage microscope, and the growth process of large-particle Sr(OH)2·8H2O was optimized and regulated online using PAT. The optimal process conditions were optimized, and large-particle Sr(OH)2·8H2O crystals were obtained by adding crystal seeds. On this basis, we proposed a seed control mechanism for Sr(OH)2·8H2O.

Details

Language :
English
ISSN :
20734352
Volume :
14
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Crystals
Publication Type :
Academic Journal
Accession number :
edsdoj.082faf0941da4ce480f515e8c8c2cc3b
Document Type :
article
Full Text :
https://doi.org/10.3390/cryst14010004