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Iron-catalyzed [4 + 2] annulation of α,β-unsaturated ketoxime acetates with enaminones toward functionalized pyridines
- Source :
- Green Synthesis and Catalysis, Vol 2, Iss 2, Pp 237-240 (2021)
- Publication Year :
- 2021
- Publisher :
- KeAi Communications Co. Ltd., 2021.
-
Abstract
- The iron-catalyzed [4 + 2] annulation of α,β-unsaturated ketoxime acetates with enaminones has been developed, providing efficient access to highly substituted pyridines in moderate to good yields. Notable features of the present strategy include low-cost catalytic system, simple and mild reaction condition and wide substrate scope. Mechanistic studies reveal that FeCl2 may directly serve as a Lewis acid to activate the α,β-unsaturated ketoxime acetates for the nucleophilic addition.
Details
- Language :
- English
- ISSN :
- 26665549
- Volume :
- 2
- Issue :
- 2
- Database :
- Directory of Open Access Journals
- Journal :
- Green Synthesis and Catalysis
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.08f2c399d4c84296b2590ecf2bb0cb48
- Document Type :
- article
- Full Text :
- https://doi.org/10.1016/j.gresc.2021.03.001