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Bench-stable Nickel(II)–aryl Complex-Catalyzed cyclotrimerisation of diynes and alkynes to synthesis multisubstituted benzene derivatives
- Source :
- Results in Chemistry, Vol 7, Iss , Pp 101523- (2024)
- Publication Year :
- 2024
- Publisher :
- Elsevier, 2024.
-
Abstract
- Herein, we report a (PPh3)2Ni(o-tolyl)Cl complex-catalyzed cyclotrimerisation reaction of diynes and alkynes to furnish multi-substituted benzene derivatives in moderate to excellent yields. This method features an air-stable catalyst, green reaction conditions, and excellent functional group tolerance. Additionally, this approach enables gram-scale synthesis, and the target product could also be further derivatised into important isoindolinone scaffolds. These demonstrate the potential application of this methodology.
- Subjects :
- Nickel catalysis
Trimerisation
Alkyne
Polysubstituted benzene
Chemistry
QD1-999
Subjects
Details
- Language :
- English
- ISSN :
- 22117156
- Volume :
- 7
- Issue :
- 101523-
- Database :
- Directory of Open Access Journals
- Journal :
- Results in Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.090784c749473a8bcdff97ea00dae2
- Document Type :
- article
- Full Text :
- https://doi.org/10.1016/j.rechem.2024.101523