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Clinical characteristics and prognostic analysis of CDKN2A/2B gene in pediatric acute lymphoblastic leukemia: a retrospective case-control study
Clinical characteristics and prognostic analysis of CDKN2A/2B gene in pediatric acute lymphoblastic leukemia: a retrospective case-control study
- Source :
- Hematology, Vol 30, Iss 1 (2025)
- Publication Year :
- 2025
- Publisher :
- Taylor & Francis Group, 2025.
-
Abstract
- In this retrospective case-control study involving 424 pediatric patients diagnosed with Pediatric Acute Lymphoblastic Leukemia (ALL), the investigation focused on analyzing the clinical characteristics and prognosis associated with the Cyclin-dependent kinase inhibitor 2A/2B (CDKN2A/2B) gene. Treatment and evaluation followed the South China Children's Leukemia Group-ALL-2016 protocol (SCCLG-ALL-2016). Among the cohort, 92 patients (21.7%) exhibited CDKN2A/2B gene deletions, with 11.1% homozygous and 10.6% heterozygous deletions. Notably, ALL patients that do have CDKN2A/2B gene deletions tended to present at an older age (P = 0.001), demonstrate hepatosplenomegaly on palpation (P
Details
- Language :
- English
- ISSN :
- 16078454
- Volume :
- 30
- Issue :
- 1
- Database :
- Directory of Open Access Journals
- Journal :
- Hematology
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.0a5e1ab84511483fb4af2fe5a4a067c6
- Document Type :
- article
- Full Text :
- https://doi.org/10.1080/16078454.2024.2439606