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Clinical characteristics and prognostic analysis of CDKN2A/2B gene in pediatric acute lymphoblastic leukemia: a retrospective case-control study

Clinical characteristics and prognostic analysis of CDKN2A/2B gene in pediatric acute lymphoblastic leukemia: a retrospective case-control study

Authors :
Shi-Mei Huang
Hui-Qin Chen
Li-Ting Liu
Ya-Ting Zhang
Jian Wang
Dun-Hua Zhou
Jian-Pei Fang
Lu-Hong Xu
Source :
Hematology, Vol 30, Iss 1 (2025)
Publication Year :
2025
Publisher :
Taylor & Francis Group, 2025.

Abstract

In this retrospective case-control study involving 424 pediatric patients diagnosed with Pediatric Acute Lymphoblastic Leukemia (ALL), the investigation focused on analyzing the clinical characteristics and prognosis associated with the Cyclin-dependent kinase inhibitor 2A/2B (CDKN2A/2B) gene. Treatment and evaluation followed the South China Children's Leukemia Group-ALL-2016 protocol (SCCLG-ALL-2016). Among the cohort, 92 patients (21.7%) exhibited CDKN2A/2B gene deletions, with 11.1% homozygous and 10.6% heterozygous deletions. Notably, ALL patients that do have CDKN2A/2B gene deletions tended to present at an older age (P = 0.001), demonstrate hepatosplenomegaly on palpation (P

Details

Language :
English
ISSN :
16078454
Volume :
30
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Hematology
Publication Type :
Academic Journal
Accession number :
edsdoj.0a5e1ab84511483fb4af2fe5a4a067c6
Document Type :
article
Full Text :
https://doi.org/10.1080/16078454.2024.2439606