Back to Search Start Over

Association between fine particulate matter and fecundability in Henan, China: A prospective cohort study

Authors :
Rong Zhang
Jun Zhao
Yue Zhang
Xiang Hong
Hongguang Zhang
Hanyue Zheng
Jingwei Wu
Yuanyuan Wang
Zuoqi Peng
Ya Zhang
Lifang Jiang
Yueshu Zhao
Qiaomei Wang
Haiping Shen
Yiping Zhang
Donghai Yan
Bei Wang
Xu Ma
Source :
Environment International, Vol 188, Iss , Pp 108754- (2024)
Publication Year :
2024
Publisher :
Elsevier, 2024.

Abstract

Objective: To investigate the relationship between ambient fine particulate matter (PM2.5) exposure and fecundability. Methods: This study included 751,270 female residents from Henan Province who participated in the National Free Pre-conception Check-up Projects during 2015–2017. Ambient cycle-specific PM2.5 exposure was assessed at the county level for each participant using satellite-based PM2.5 concentration data at 1-km resolution. Cox proportional hazards models with time-varying exposure were used to estimate the association between fecundability and PM2.5 exposure, adjusted for potential individual risk factors. Results: During the study period, 568,713 participants were pregnant, monthly mean PM2.5 concentrations varied from 25.5 to 114.0 µg/m3 across study areas. For each 10 µg/m3 increase in cycle-specific PM2.5, the hazard ratio for fecundability was 0.951 (95 % confidence interval: 0.950–0.953). The association was more pronounced in women who were older, with urban household registration, history of pregnancy, higher body mass index (BMI), hypertension, without exposure to tobacco, or whose male partners were older, with higher BMI, or hypertension. Conclusion: In this population-based prospective cohort, ambient cycle-specific PM2.5 exposure was associated with reduced fecundability. These findings may support the adverse implications of severe air pollution on reproductive health.

Details

Language :
English
ISSN :
01604120
Volume :
188
Issue :
108754-
Database :
Directory of Open Access Journals
Journal :
Environment International
Publication Type :
Academic Journal
Accession number :
edsdoj.0a9e80e93487ea6e0d8e094bf4386
Document Type :
article
Full Text :
https://doi.org/10.1016/j.envint.2024.108754