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Angioimmunoblastic T-Cell Lymphoma with Polyclonal Proliferation of Plasma Cells: A Cautionary Note for Flow Cytometry Interpretations

Authors :
Woo Yong Shin
Hae In Bang
Jung-Ah Kim
Jieun Kim
Rojin Park
Source :
Korean Journal of Clinical Laboratory Science, Vol 54, Iss 1, Pp 68-72 (2022)
Publication Year :
2022
Publisher :
The Korean Society for Clinical Laboratory Science, 2022.

Abstract

Angioimmunoblastic T-cell lymphoma (AITL) is a lymphoproliferative disorder of mature T follicular helper cells. Atypical lymphoid cells were observed in the bone marrow of an 80-year-old woman, and the flow cytometric determined immunophenotypes of B-cells were unusual, that is, CD19+, CD20-, and CD22- with lambda light chain restriction. Initially, we suspected BM involvement of B-cell lymphoma based on the presence of abnormal B-cells. However, the patient was diagnosed with AITL involving BM. A re-analysis of flow cytometric immunophenotyping revealed a minor, aberrant T-cell population, and the lambda light chain restriction observed by surface staining was considered non-specific binding. This case demonstrates B-cells in patients with EBV-positive T-cell lymphoma may exhibit immunophenotypes resembling those of plasma cells, and that proliferation of abnormal B-cells or plasma cells could also potentially mask underlying T-cell lymphoma. A more integrated approach is required for accurate diagnosis.

Details

Language :
English, Korean
ISSN :
17383544 and 22881662
Volume :
54
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Korean Journal of Clinical Laboratory Science
Publication Type :
Academic Journal
Accession number :
edsdoj.0b54ec0e700f429e84e70091d70aa961
Document Type :
article
Full Text :
https://doi.org/10.15324/kjcls.2022.54.1.68