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Impact of Biological Therapies on the Immune Response after Pneumococcal Vaccination in Patients with Autoimmune Inflammatory Diseases

Authors :
Patricia Richi
Jose Yuste
Teresa Navío
Laura González-Hombrado
Marina Salido
Israel Thuissard-Vasallo
Ana Jiménez-Díaz
Jesús Llorente
Laura Cebrián
Leticia Lojo
Martina Steiner
Tatiana Cobo
María Dolores Martín
Marta García-Castro
Patricia Castro
Santiago Muñoz-Fernández
Source :
Vaccines, Vol 9, Iss 3, p 203 (2021)
Publication Year :
2021
Publisher :
MDPI AG, 2021.

Abstract

Patients with different autoimmune inflammatory diseases (AIID) on biological therapy are at risk of pneumococcal disease. Adults with inflammatory arthropathies, connective tissue diseases, psoriasis, or inflammatory bowel disease on biological therapy such as anti-TNFα, rituximab, tocilizumab, abatacept, or anakinra were included in this study. Patients completed a protocol combining the pneumococcal vaccines PCV13 and PPV23. Immune response against pneumococcal serotypes 1, 3, 7F, 14, 19A, and 19F were assessed evaluating functional antibodies by an opsonophagocytosis killing assay (OPKA). In this study, 182 patients with AIID completed the sequential vaccination protocol. Patients on etanercept tended to achieve OPKA titers against a larger number of serotypes than the rest of patients on other biological therapies, while adalimumab was associated to a lower number of serotypes with OPKA titers. Rituximab was not associated with a worse response when compared with the rest of biological agents. Not glucocorticoids, nor synthetic disease-modifying antirheumatic drugs, interfered with the immune response. OPKA titers against serotype 3 which is one of the most prevalent, was obtained in 44% of patients, increasing up to 58% in those on etanercept. Hence, almost 50% of patients on biological therapy achieved functional antibodies after the administration of a complete pneumococcal vaccination protocol.

Details

Language :
English
ISSN :
2076393X
Volume :
9
Issue :
3
Database :
Directory of Open Access Journals
Journal :
Vaccines
Publication Type :
Academic Journal
Accession number :
edsdoj.0b7b51666d9d401fae5073e96b3da8e0
Document Type :
article
Full Text :
https://doi.org/10.3390/vaccines9030203