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Efficient 3D light-sheet imaging of very large-scale optically cleared human brain and prostate tissue samples

Authors :
Anna Schueth
Sven Hildebrand
Iryna Samarska
Shubharthi Sengupta
Annemarie Kiessling
Andreas Herrler
Axel zur Hausen
Michael Capalbo
Alard Roebroeck
Source :
Communications Biology, Vol 6, Iss 1, Pp 1-15 (2023)
Publication Year :
2023
Publisher :
Nature Portfolio, 2023.

Abstract

A light-sheet microscopy prototype, the cleared-tissue dual view Selective Plane Illumination Microscope (ct-dSPIM), is presented and shown to enable quantitative assessment of large-scale human tissue samples in 3D with clinical potential.

Subjects

Subjects :
Biology (General)
QH301-705.5

Details

Language :
English
ISSN :
23993642
Volume :
6
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Communications Biology
Publication Type :
Academic Journal
Accession number :
edsdoj.0b83e129d249470b9c0906321bbf7562
Document Type :
article
Full Text :
https://doi.org/10.1038/s42003-023-04536-4