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Linear Aminolipids with Moderate Antimicrobial Activity from the Antarctic Gram-Negative Bacterium Aequorivita sp.

Authors :
Giuseppina Chianese
Fortunato Palma Esposito
Delphine Parrot
Colin Ingham
Donatella de Pascale
Deniz Tasdemir
Source :
Marine Drugs, Vol 16, Iss 6, p 187 (2018)
Publication Year :
2018
Publisher :
MDPI AG, 2018.

Abstract

The combination of LC-MS/MS based metabolomics approach and anti-MRSA activity-guided fractionation scheme was applied on the Gram-negative bacterium Aequorivita sp. isolated from shallow Antarctic sea sediment using a miniaturized culture chip technique. This methodology afforded the isolation of three new (1–3) and four known (4–7) N-terminal glycine- or serine-bearing iso-fatty acid amides esterified with another iso-fatty acid through their C-3 hydroxy groups. The chemical structures of the new compounds were elucidated using a set of spectroscopic (NMR, [α]D and FT-IR) and spectrometric (HRMS, HRMS/MS) methods. The aminolipids possessing an N-terminal glycine unit (1, 2, 4, 5) showed moderate in vitro antimicrobial activity against MRSA (IC50 values 22–145 μg/mL). This is the first in-depth chemistry and biological activity study performed on the microbial genus Aequorivita.

Details

Language :
English
ISSN :
16603397
Volume :
16
Issue :
6
Database :
Directory of Open Access Journals
Journal :
Marine Drugs
Publication Type :
Academic Journal
Accession number :
edsdoj.0c160fb7c5d449beaf09cadc184e4712
Document Type :
article
Full Text :
https://doi.org/10.3390/md16060187