Effect of swimming training and arbutin supplement on cardiac antioxidant enzymes and oxidative stress in diabetic rats

Background and Objective: Oxidative stress plays a major role in the structural and functional changes of the myocardium due to diabetes. This study was done to determine the effect of swimming training and arbutin supplement on cardiac antioxidant enzymes and oxidative stress in diabetic rats. Methods: In this experimental study, 42 male Wistar rats were randomly allocated into 6 groups including control, diabetes, Arbutin, diabetes+Arbutin, diabetes+exercise and diabetes+ exercise + Arbutin (combined). Diabetes induced using alloxan (90 mg/kg/bw, intraperitoneally). Arbutin (50 mg/kg/bw, ip) was administered for 5 days a week. The exercise consisted of swimming training at 5 min to 36 min per day, 5 days a week for 6 weeks. Renal Malondialdehyde, catalase level and superoxide dismutase (SOD) activity were evaluated in animals. Results: Diabetes significantly increased cardiac Malondialdehyde level and decreased cardiac SOD activity and catalase level (P