Back to Search
Start Over
A potent series targeting the malarial cGMP-dependent protein kinase clears infection and blocks transmission
- Source :
- Nature Communications, Vol 8, Iss 1, Pp 1-9 (2017)
- Publication Year :
- 2017
- Publisher :
- Nature Portfolio, 2017.
-
Abstract
- Protein kinases are promising drug targets for treatment of malaria. Here, starting with a medicinal chemistry approach, Baker et al. generate an imidazopyridine that selectively targets Plasmodium falciparum PKG, inhibits blood stage parasite growth in vitro and in mice and blocks transmission to mosquitoes.
- Subjects :
- Science
Subjects
Details
- Language :
- English
- ISSN :
- 20411723 and 48607312
- Volume :
- 8
- Issue :
- 1
- Database :
- Directory of Open Access Journals
- Journal :
- Nature Communications
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.0c48607312374096801bf91f077ff9c0
- Document Type :
- article
- Full Text :
- https://doi.org/10.1038/s41467-017-00572-x