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DNA vaccination protects mice against Zika virus-induced damage to the testes

Authors :
Bryan D. Griffin
Kar Muthumani
Bryce M. Warner
Anna Majer
Mable Hagan
Jonathan Audet
Derek R. Stein
Charlene Ranadheera
Trina Racine
Marc-Antoine De La Vega
Jocelyne Piret
Stephanie Kucas
Kaylie N. Tran
Kathy L. Frost
Christine De Graff
Geoff Soule
Leanne Scharikow
Jennifer Scott
Gordon McTavish
Valerie Smid
Young K. Park
Joel N. Maslow
Niranjan Y. Sardesai
J. Joseph Kim
Xiao-jian Yao
Alexander Bello
Robbin Lindsay
Guy Boivin
Stephanie A. Booth
Darwyn Kobasa
Carissa Embury-Hyatt
David Safronetz
David B. Weiner
Gary P. Kobinger
Source :
Nature Communications, Vol 8, Iss 1, Pp 1-8 (2017)
Publication Year :
2017
Publisher :
Nature Portfolio, 2017.

Abstract

Zika virus (ZIKV) can persist in human semen and sperm, which can result in sexual transmission. Here, Griffinet al. show that a DNA vaccine, expressing ZIKV pre-membrane and envelope proteins, protects mice from infection-associated damage to testes and sperm, and prevents viral persistence in testes.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723
Volume :
8
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.0c82ce7b193e4897a52f784c15fa050c
Document Type :
article
Full Text :
https://doi.org/10.1038/ncomms15743