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Apolipoprotein A-IV binds αIIbβ3 integrin and inhibits thrombosis
- Source :
- Nature Communications, Vol 9, Iss 1, Pp 1-18 (2018)
- Publication Year :
- 2018
- Publisher :
- Nature Portfolio, 2018.
-
Abstract
- Activation of integrin αIIbβ3 at the surface of platelets is required for their aggregation and for thrombus formation. Here Xu et al. identify apolipoprotein A-IV as a novel ligand for platelet αIIbβ3 integrin, and find it inhibits platelet aggregation and thrombosis.
- Subjects :
- Science
Subjects
Details
- Language :
- English
- ISSN :
- 20411723
- Volume :
- 9
- Issue :
- 1
- Database :
- Directory of Open Access Journals
- Journal :
- Nature Communications
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.0ce3127e01234b83a479b73aff61e66c
- Document Type :
- article
- Full Text :
- https://doi.org/10.1038/s41467-018-05806-0