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Pedalitin could regulate lipid metabolism and attenuate inflammatory factors in a non-alcoholic fatty liver disease cell model

Authors :
Wanying He
Yaying Yu
Hui He
Qian Huang
Zhiting Liu
Fan Yang
Lin Zhou
Source :
Journal of Holistic Integrative Pharmacy, Vol 5, Iss 4, Pp 314-322 (2024)
Publication Year :
2024
Publisher :
KeAi Communications Co., Ltd., 2024.

Abstract

Nonalcoholic fatty liver disease (NAFLD) is an escalating global health issue, leading to liver fat accumulation, inflammation, fibrosis, and potential liver failure. In our preliminary network pharmacological study, it was hypothesized that Pedalitin (PED), a flavonoid found in black sesame plants, might exhibit protective effects against NAFLD. However, the effects and mechanisms of PED underlying its action on NAFLD are not yet fully understood. This study aimed to explore the potential effects and mechanisms of PED on NAFLD using a combination of network pharmacology, molecular docking, and the LO2 cell model. Potential targets for PED and NAFLD were predicted through public databases. Protein-protein interaction (PPI) networks were constructed, and Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses were performed. Molecular docking was used to predict the target genes that could bind to PED. In vitro experiments using the LO2 cell model indicated that PED significantly reduced TG level (p ​

Details

Language :
English
ISSN :
27073688
Volume :
5
Issue :
4
Database :
Directory of Open Access Journals
Journal :
Journal of Holistic Integrative Pharmacy
Publication Type :
Academic Journal
Accession number :
edsdoj.0d0452a741ce4d64aa94cbbe1afa756a
Document Type :
article
Full Text :
https://doi.org/10.1016/j.jhip.2024.11.003