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HER1 Vaccine: An autologous EGFR vaccine candidate to treat epithelial tumors

Authors :
Belinda Sánchez
Yeranddy Aguiar
Diana R Hernández
Greta Garrido
Rolando Pérez
Luis E Fernández
Source :
Biotecnología Aplicada, Vol 26, Iss 4, Pp 342-344
Publisher :
Elfos Scientiae.

Abstract

The Epidermal Growth Factor Receptor (EGFR) plays an essential role in regulating neoplastic processes. EGFR over-expression in many human epithelial tumors has been correlated with disease progression and bad prognosis. Passive EGFR-directed immunotherapy has been introduced in medical oncology practice, but no active specific approaches have been used. We designed a vaccine candidate based on the extracellular domain (ECD) of human EGFR (HER1), and the homologous vaccine for mice based on murine EGFR. This vaccine candidate uses the Very Small-Sized Proteoliposomes from Neisseria meningitidis (VSSP) and Montanide ISA 51-VG as adjuvants. The autologous vaccine circumvents the tolerance to self EGFR by inducing a specific immune response with an anti-metastatic effect on EGFR+ tumors. The vaccine candidate based on HER1-ECD induced anti-EGFR polyclonal antibodies (PAb) that bind EGFR+ human tumor cell lines from different tissues. These anti-EGFR PAb abrogate ligand-dependent EGFR phosphorylation, provoking the inhibition of tumor cell growth and apoptosis. Preclinical results further encouraged the evaluation of the HER1 vaccine candidate in phase I clinical trials

Subjects

Subjects :
Biotechnology
TP248.13-248.65

Details

Language :
English, Spanish; Castilian
ISSN :
10272852
Volume :
26
Issue :
4
Database :
Directory of Open Access Journals
Journal :
Biotecnología Aplicada
Publication Type :
Academic Journal
Accession number :
edsdoj.0d5a1ed749754134a7cfcea67828a89d
Document Type :
article