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Sinopharm (HB02)-associated vaccine-induced immune thrombotic thrombocytopenia: a case report

Sinopharm (HB02)-associated vaccine-induced immune thrombotic thrombocytopenia: a case report

Authors :
Mohammad Sistanizad
Tahereh Sabaghian
Hossein Amini
Fahimeh Hadavand
Mahmood Nabavi
Mehran Kouchek
Mir Mohammad Miri
Sara Salarian
Seyedpouzhia Shojaei
Omid Moradi
Source :
Journal of Medical Case Reports, Vol 17, Iss 1, Pp 1-5 (2023)
Publication Year :
2023
Publisher :
BMC, 2023.

Abstract

Abstract Background Vaccine-induced thrombotic thrombocytopenia is associated with the coronavirus disease 2019 vaccines. It has been reported by vector-based vaccines. To the best of our knowledge, there is no report about vaccine-induced thrombotic thrombocytopenia in whole-virus vaccines. We are presenting the first case of vaccine-induced thrombotic thrombocytopenia with this type of vaccine. Case presentation An 18-year-old male Caucasian patient with complaints of severe abdominal, low back, and lower extremity pain presented to the medical center. He received the first dose of the Sinopharm (HB02) vaccine against coronavirus disease 2019 10 days before hospital attendance. In the laboratory examination, decreased platelet count and increased D-dimer were observed. During hospital admission, the diagnosis of pulmonary embolism was reached. He received vaccine-induced thrombotic thrombocytopenia therapy consisting of intravenous immune globulin and direct oral anticoagulant. Platelet count increased and he was discharged after 1 month. Conclusion This case highlights the possibility of vaccine-induced thrombotic thrombocytopenia occurrence by whole-virus coronavirus disease 2019 vaccines. Compared with vector-based vaccines, this phenomenon is rare for whole-virus vaccines. More studies on this type of vaccine regarding thrombotic thrombocytopenia should be considered.

Details

Language :
English
ISSN :
17521947
Volume :
17
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Journal of Medical Case Reports
Publication Type :
Academic Journal
Accession number :
edsdoj.0d83d0ac54c44340a6b698594db76c86
Document Type :
article
Full Text :
https://doi.org/10.1186/s13256-023-04086-7