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Comparative Efficacy of Single Pill Combinations of Azilsartan Medoxomil/Chlorthalidone and Losartan/Hydrochlorothiazide in Patients with Hypertension and Heart Failure with Preserved Ejection Fraction
- Source :
- Рациональная фармакотерапия в кардиологии, Vol 18, Iss 2, Pp 127-134 (2022)
- Publication Year :
- 2022
- Publisher :
- Столичная издательская компания, 2022.
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Abstract
- Aim. To study the effects of azilsartan medoxomil/chlorthalidone (AZM/CTD) and losartan/hydrochlorothiazide (LOS/HCT) combinations for NTproBNP levels, 6-minute walk test results, hydration status along with their antihypertensive efficacy according to clinical and 24-hour blood pressure in patients with hypertension and heart failure with preserved ejection fraction (HFpEF).Material and methods. An open randomized study included 56 patients with uncontrolled or untreated hypertension and HFpEF. Patients randomized to receive the AZM/CTD 40/12.5 mg/day (group 1; n=28) or LOS/HCT 100/12.5 (group 2; n=28) within 4 weeks. Patients who did not achieve the target BP
Details
- Language :
- English, Russian
- ISSN :
- 18196446 and 22253653
- Volume :
- 18
- Issue :
- 2
- Database :
- Directory of Open Access Journals
- Journal :
- Рациональная фармакотерапия в кардиологии
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.0da881d5eb745e98bd8961a87fcf4f9
- Document Type :
- article
- Full Text :
- https://doi.org/10.20996/1819-6446-2022-04-01