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Anti-viral memory T cell responses in the absence of IgG production in a COVID-19 convalescent individual
- Source :
- National Science Open, Vol 1 (2022)
- Publication Year :
- 2022
- Publisher :
- Science Press, 2022.
-
Abstract
- Cellular and humoral immunity are both important in host defense against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Although defects in SARS-CoV-2-specific T cell immunity have been found in patients with severe lung pathology, it is still largely unclear whether virus-specific T cells are sufficient for host protection. Here, we found that in a previously characterized cohort of convalescent subjects, one individual, though lacking detectable anti-viral neutralizing IgG antibodies, showed virus-specific T cell responses, both in CD4+ and CD8+ T cells. SARS-CoV-2-specific T cells in this and other individuals are maintained for up to 10 months. This study thus further supports a critical role of T cells in host defense against SARS-CoV-2, offering new insights into the design and evaluation of COVID-19 vaccines.
Details
- Language :
- English
- ISSN :
- 20971168
- Volume :
- 1
- Database :
- Directory of Open Access Journals
- Journal :
- National Science Open
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.0dcc5e1be2b6471d8792148a94893a17
- Document Type :
- article
- Full Text :
- https://doi.org/10.1360/nso/20220009