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Epigenetic Regulation of Dental Pulp Stem Cell Fate

Authors :
Dan Zhou
Lu Gan
Yiran Peng
Yachuan Zhou
Xin Zhou
Mian Wan
Yi Fan
Xin Xu
Xuedong Zhou
Liwei Zheng
Wei Du
Source :
Stem Cells International, Vol 2020 (2020)
Publication Year :
2020
Publisher :
Hindawi Limited, 2020.

Abstract

Epigenetic regulation, mainly involving DNA methylation, histone modification, and noncoding RNAs, affects gene expression without modifying the primary DNA sequence and modulates cell fate. Mesenchymal stem cells derived from dental pulp, also called dental pulp stem cells (DPSCs), exhibit multipotent differentiation capacity and can promote various biological processes, including odontogenesis, osteogenesis, angiogenesis, myogenesis, and chondrogenesis. Over the past decades, increased attention has been attracted by the use of DPSCs in the field of regenerative medicine. According to a series of studies, epigenetic regulation is essential for DPSCs to differentiate into specialized cells. In this review, we summarize the mechanisms involved in the epigenetic regulation of the fate of DPSCs.

Subjects

Subjects :
Internal medicine
RC31-1245

Details

Language :
English
ISSN :
1687966X and 16879678
Volume :
2020
Database :
Directory of Open Access Journals
Journal :
Stem Cells International
Publication Type :
Academic Journal
Accession number :
edsdoj.0df6f8922dc4e25918bfc98b3d95d25
Document Type :
article
Full Text :
https://doi.org/10.1155/2020/8876265