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Epigenetic Regulation of Dental Pulp Stem Cell Fate
- Source :
- Stem Cells International, Vol 2020 (2020)
- Publication Year :
- 2020
- Publisher :
- Hindawi Limited, 2020.
-
Abstract
- Epigenetic regulation, mainly involving DNA methylation, histone modification, and noncoding RNAs, affects gene expression without modifying the primary DNA sequence and modulates cell fate. Mesenchymal stem cells derived from dental pulp, also called dental pulp stem cells (DPSCs), exhibit multipotent differentiation capacity and can promote various biological processes, including odontogenesis, osteogenesis, angiogenesis, myogenesis, and chondrogenesis. Over the past decades, increased attention has been attracted by the use of DPSCs in the field of regenerative medicine. According to a series of studies, epigenetic regulation is essential for DPSCs to differentiate into specialized cells. In this review, we summarize the mechanisms involved in the epigenetic regulation of the fate of DPSCs.
- Subjects :
- Internal medicine
RC31-1245
Subjects
Details
- Language :
- English
- ISSN :
- 1687966X and 16879678
- Volume :
- 2020
- Database :
- Directory of Open Access Journals
- Journal :
- Stem Cells International
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.0df6f8922dc4e25918bfc98b3d95d25
- Document Type :
- article
- Full Text :
- https://doi.org/10.1155/2020/8876265