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Effect of minor gallium addition on corrosion, passivity, and antibacterial behaviour of novel β-type Ti–Nb alloys

Authors :
Adnan Akman
Ludovico Andrea Alberta
Paula Milena Giraldo-Osorno
Adam Benedict Turner
Martin Hantusch
Anders Palmquist
Margarita Trobos
Mariana Calin
Annett Gebert
Source :
Journal of Materials Research and Technology, Vol 25, Iss , Pp 4110-4124 (2023)
Publication Year :
2023
Publisher :
Elsevier, 2023.

Abstract

Metastable Ti–Nb alloys are promising bone-implant materials due to improved mechanical biofunctionality and biocompatibility. To overcome increasing bacterial infection risk, alloying with antibacterial elements is a promising strategy. This study investigates the effect of minor gallium (Ga) additions (4, 8 wt% Ga) to as-cast and solution-treated β-type Ti–45Nb-based alloy (96(Ti–45Nb)-4Ga, 92(Ti–45Nb)-8Ga (wt.%)) on corrosion and passive film properties, as well as cytocompatibility and antibacterial activity. The electrochemical properties were evaluated by potentiodynamic polarization, electrochemical impedance spectroscopy (EIS), and Mott-Schottky analyses in phosphate-buffered saline (PBS). X-ray photoelectron spectroscopy (XPS) was performed to analyze the chemical composition of passive films. Early adhesion and viability of macrophages and Staphylococcus aureus were assessed by nucleocounting and colony-forming unit counting, respectively. The results showed that high corrosion resistance and passive film properties of Ti–45Nb are retained and even slightly improved with Ga. EIS results revealed that Ga addition improves the passive film resistance. XPS measurements of 92(Ti–45Nb)-8Ga show that the passive film contains Ti-, Nb- and Ga-based oxides, implying the formation of mixed (Ti–Nb-Ga) oxides. In addition, marginal Ga ion release rate was detected under free corrosion conditions. Therefore, it can be assumed that Ga species may contribute to passive film formation on Ga-containing alloys. The 92(Ti–45Nb)-8Ga elicited an antibacterial effect against S. aureus compared to cp-Ti at 4 h. Moreover, Ga-containing alloys showed good cytocompatibility with THP-1 macrophages at 24 h. In conclusion, it was demonstrated that Ga additions to Ti–45Nb are beneficial to corrosion resistance and showed promising initial host and bacterial interactions.

Details

Language :
English
ISSN :
22387854
Volume :
25
Issue :
4110-4124
Database :
Directory of Open Access Journals
Journal :
Journal of Materials Research and Technology
Publication Type :
Academic Journal
Accession number :
edsdoj.0dfa0d8df2c94f46bde50c1e1b89d836
Document Type :
article
Full Text :
https://doi.org/10.1016/j.jmrt.2023.06.219