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The Correlation between Lung Ultrasound and Pathology in Rat Model of Monocrotaline-Induced Pulmonary Hypertension

Authors :
Yan-Fen Zhong
Bin-Bin Liang
Xiao-Feng Zhang
null Ji-Wu
Source :
Canadian Respiratory Journal, Vol 2024 (2024)
Publication Year :
2024
Publisher :
Hindawi Limited, 2024.

Abstract

Pulmonary hypertension (PH) is a progressive and complex pulmonary vascular disease with poor prognosis. The aim of this study was to provide a new understanding of the lung pathology of disease and a noninvasive method in monitoring the establishment of animal models for basic and clinical studies of PH, indeed to explore clinical application value of lung ultrasound for patients with PH. Totally 32 male SD rats were randomly divided into control group, MCT (monocrotaline) group, PDTC (pyrrolidine dithiocarbamate) group, and NS (normal saline) group. Rats in the MCT group, PDTC group, and NS group received single intraperitoneal injection of MCT, while the control group received the same dose of NS. Then, PDTC group and NS group received PDTC and NS daily for treatment at the end of the model. Each group received lung ultrasound examination and measurement of pulmonary arterial pressure (PAP). Then, the rats were sacrificed to take the lung specimens to being observed. The ultrasound and pathological results were analyzed with a semiquantitative score. With the pulmonary artery pressure increases, the MCT group had a higher pulmonary ultrasound score and pathological score compared with the control group (p 0.8, p 0.8, p

Details

Language :
English
ISSN :
19167245
Volume :
2024
Database :
Directory of Open Access Journals
Journal :
Canadian Respiratory Journal
Publication Type :
Academic Journal
Accession number :
edsdoj.0e72d15309174ea1a19a269fe3cf6b7f
Document Type :
article
Full Text :
https://doi.org/10.1155/2024/6619471