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Concentration of platelets and growth factors in platelet-rich plasma from Goettingen minipigs
- Source :
- GMS Interdisciplinary Plastic and Reconstructive Surgery DGPW, Vol 3, p Doc11 (2014)
- Publication Year :
- 2014
- Publisher :
- German Medical Science GMS Publishing House, 2014.
-
Abstract
- In minipigs little is known about the concentration of growth factors in plasma, despite their major role in several patho-physiological processes such as healing of fractures. This prompted us to study the concentration of platelets and selected growth factors in plasma and platelet-rich plasma (PRP) preparation of sixteen Goettingen minipigs. Platelet concentrations increased significantly in PRP in comparison to native blood plasma. Generally, significant increase in the concentration of all growth factors tested was observed in the PRP in comparison to the corresponding plasma or serum. Five of the plasma samples examined contained detectable levels of bone morphogenic protein 2 (BMP-2) whereas eleven of the plasma or serum samples contained minimal amounts of vascular endothelial growth factor (VEGF) and platelet-derived growth factor (PDGF-bb) respectively. On the other hand variable concentrations of bone morphogenic protein 7 (BMP-7) and transforming growth factor β1 (TGF-β1) were measured in all plasma samples. In contrast, all PRP samples contained significantly increased amounts of growth factors. The level of BMP-2, BMP-7, TGF-β1, VEGF and PDGF-bb increased by 17.6, 1.5, 7.1, 7.2 and 103.3 fold, in comparison to the corresponding non-enriched preparations. Moreover significant positive correlations were found between platelet count and the concentrations of BMP-2 (r=0.62, p
- Subjects :
- growth factors
minipig
platelet-rich plasma
Surgery
RD1-811
Subjects
Details
- Language :
- German, English
- ISSN :
- 21938091
- Volume :
- 3
- Database :
- Directory of Open Access Journals
- Journal :
- GMS Interdisciplinary Plastic and Reconstructive Surgery DGPW
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.0f110dc0d4a3e9e6d4f2d6bb56e01
- Document Type :
- article
- Full Text :
- https://doi.org/10.3205/iprs000052