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Exploring the Connection Between Bacterial Biofilms and Renal Calculi: A Comprehensive Review

Authors :
A. Mohankumar
Raghuram Ganesh
Priyadarshini Shanmugam
Source :
Journal of Pure and Applied Microbiology, Vol 18, Iss 4, Pp 2262-2283 (2024)
Publication Year :
2024
Publisher :
Journal of Pure and Applied Microbiology, 2024.

Abstract

Bacterial biofilms, structured communities of microorganisms enmeshed in an extracellular matrix, have emerged as significant players in various pathological processes. Renal calculi, commonly known as kidney stones, pose a prevalent medical concern, and recent research has highlighted the potential influence of bacterial biofilms in their formation and persistence. This review explores the development of biofilms on the surface of urinary tract stones and how they create a favorable environment for the colonization of bacteria. This colonization, in turn, can lead to chronic infections, stone enlargement, and recurrent stone formation. This review offers a comprehensive exploration of the dynamic interplay between bacterial biofilms and renal calculi. It emphasizes the role of biofilm-related mechanisms in chronic infections, inflammation, and mineral deposition, underscoring the potential for innovative therapeutic strategies aimed at managing and preventing biofilm-associated renal calculi.

Details

Language :
English
ISSN :
09737510 and 2581690X
Volume :
18
Issue :
4
Database :
Directory of Open Access Journals
Journal :
Journal of Pure and Applied Microbiology
Publication Type :
Academic Journal
Accession number :
edsdoj.0f1820281ff84e0098802d318a3aaa0a
Document Type :
article
Full Text :
https://doi.org/10.22207/JPAM.18.4.44