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Efficacy and Safety of Acute Phase Intensive Electrical Muscle Stimulation in Frail Older Patients with Acute Heart Failure: Results from the ACTIVE-EMS Trial

Authors :
Shinya Tanaka
Kentaro Kamiya
Yuya Matsue
Ryusuke Yonezawa
Hiroshi Saito
Nobuaki Hamazaki
Ryota Matsuzawa
Kohei Nozaki
Masashi Yamashita
Kazuki Wakaume
Yoshiko Endo
Emi Maekawa
Minako Yamaoka-Tojo
Takaaki Shiono
Takayuki Inomata
Junya Ako
Source :
Journal of Cardiovascular Development and Disease, Vol 9, Iss 4, p 99 (2022)
Publication Year :
2022
Publisher :
MDPI AG, 2022.

Abstract

As frailty in older patients with acute heart failure (AHF) has an adverse effect on clinical outcomes, the addition of electrical muscle stimulation (EMS) to exercise-based early rehabilitation may improve the effects of treatment. Post hoc analysis was performed on a randomized controlled study for clinical outcomes and prespecified subgroups (ACTIVE-EMS: UMIN000019551). In this trial, 31 AHF patients aged ≥ 75 years with frailty (Short Physical Performance Battery [SPPB] score 4–9) were randomized 1:1 to receive treatment with an early rehabilitation program only (n = 16) or early rehabilitation with add-on EMS therapy (n = 15) for 2 weeks. Changes in physical function and cognitive function between baseline and after two weeks of treatment were assessed. There were no adverse events during the EMS period. The EMS group showed significantly greater changes in quadriceps’ isometric strength and SPPB compared to the control group, and EMS therapy showed uniform effects in the prespecified subgroups. There were no significant differences in the changes in other indexes of physical function and cognitive function between groups. There was no significant difference in the rate of heart failure hospitalization at 90 days between groups. In conclusion, older AHF patients with frailty showed greater improvement in lower extremity function with the addition of EMS therapy to early rehabilitation without adverse events.

Details

Language :
English
ISSN :
23083425
Volume :
9
Issue :
4
Database :
Directory of Open Access Journals
Journal :
Journal of Cardiovascular Development and Disease
Publication Type :
Academic Journal
Accession number :
edsdoj.0f4a9cfe13c742769dfda541cff94f72
Document Type :
article
Full Text :
https://doi.org/10.3390/jcdd9040099