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Correlation between the extent of smoking, salivary protein profiles, and dental caries in young adult smokers
- Source :
- Saudi Dental Journal, Vol 33, Iss 7, Pp 533-537 (2021)
- Publication Year :
- 2021
- Publisher :
- Elsevier, 2021.
-
Abstract
- Context.Proteins in the saliva are one of the defense mechanism factors that can protect the oral cavity from disease. However, smoking might affect the properties of saliva. Aim: To determine the differences in salivary protein profiles and total concentrations in smokers and non-smokers and their correlation with dental caries severity as indicated by the Decayed, Missing, Filled-Teeth (DMF-T) scores. Methods and material: This cross-sectional study included 25 smokers and 25 non-smokers. The DMF-T scores were recorded. The total salivary protein was measured by the Bradford method, and the profile proteins were determined by sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE). Results: The average of salivary protein concentration in smokers was lower than that in non-smokers (551.486 µg/mL versus 765.361 µg/mL), but the difference was not statistically significant (P > 0.05). Further correlation analyses showed a negative correlation between the concentration of proteins based on the extent of smoking. A weak negative correlation was found between protein concentration and DMF-T scores (r = −0.239). Dominant salivary protein bands of 11.6 kDa and 54.5 kDa were found in smokers and 27 kDa, 60 kDa, and 94.5 kDa were found in non-smokers. Conclusion: Different protein bands appeared in smokers and non-smokers. There was a weak correlation between protein concentration, DMF-T scores, and the extent of smoking.
Details
- Language :
- English
- ISSN :
- 10139052
- Volume :
- 33
- Issue :
- 7
- Database :
- Directory of Open Access Journals
- Journal :
- Saudi Dental Journal
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.0f4dfe0cf7844d49280d14cae09f640
- Document Type :
- article
- Full Text :
- https://doi.org/10.1016/j.sdentj.2020.09.002