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Efficacy of Albis for the Prevention of Gastric Mucosal Injury Concomitant with the Use of Low-Dose Aspirin: A Prospective, Randomized, Placebo-Controlled Study

Authors :
Sang Gyun Kim
Nayoung Kim
Sung Kwan Shin
In Kyung Sung
Su Jin Hong
Hyo-Jin Park
Source :
Clinical Endoscopy, Vol 50, Iss 2, Pp 179-184 (2017)
Publication Year :
2017
Publisher :
Korean Society of Gastrointestinal Endoscopy, 2017.

Abstract

Background/Aims Long-term use of aspirin can be a risk factor of peptic ulcer diseases. The aim of this study was to evaluate the efficacy of Albis (Daewoong Pharmaceutical Co., Ltd.) for the prevention of gastric mucosal injury caused by aspirin. Methods Aspirin users were enrolled and randomized into the Albis or placebo group. Screening and follow-up endoscopy were performed for modified Lanza scores (MLSs). Primary outcome was measured by the incidence rate of peptic ulcer, and secondary outcomes were measured by the incidence rate of gastritis, improvement in MLS and subjective symptoms. Results In total, 81 aspirin users were randomized, 43 in the Albis group and 38 in the placebo group. There was no incidence of peptic ulcer in both groups. The incidence of gastritis was significantly higher in the placebo group (44.4% vs. 10.0%, p=0.003); however, the scores of mucosal edema, hyperemia and hemorrhage were not statistically different between the two groups (p>0.05). The frequency of subjective symptoms were more improved in the Albis group than in the placebo group (p=0.023). Conclusions The incidence of gastritis was lower in the group that received low-dose aspirin and Albis. The development of peptic ulcer due to long-term use of aspirin might be prevented with concomitant use of Albis.

Details

Language :
English
ISSN :
22342400 and 22342443
Volume :
50
Issue :
2
Database :
Directory of Open Access Journals
Journal :
Clinical Endoscopy
Publication Type :
Academic Journal
Accession number :
edsdoj.0f6be8925e5a4510928ea731459f3671
Document Type :
article
Full Text :
https://doi.org/10.5946/ce.2016.031