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Six-minute walk test as clinical end point in cardiomyopathy clinical trials, including ATTR-CM: a systematic literature review
- Source :
- Journal of Comparative Effectiveness Research, Vol 13, Iss 7 (2024)
- Publication Year :
- 2024
- Publisher :
- Becaris Publishing Limited, 2024.
-
Abstract
- Aim: The six-minute walk test (6MWT) is a common measure of functional capacity in patients with heart failure (HF). Primary clinical study end points in cardiomyopathy (CM) trials, including transthyretin-mediated amyloidosis with CM (ATTR-CM), are often limited to hospitalization and mortality. Objective: To investigate the relationship between the 6MWT and hospitalization or mortality in CM, including ATTR-CM. Method: A PRISMA-guided systematic literature review was conducted using search terms for CM, 6MWT, hospitalization and mortality. Results: Forty-one studies were identified that reported 6MWT data and hospitalization or mortality data for patients with CM. The data suggest that a greater 6MWT distance is associated with a reduced risk of hospitalization or mortality in CM. Conclusion: The 6MWT is an accepted alternative end point in CM trials, including ATTR-CM.
Details
- Language :
- English
- ISSN :
- 20426313
- Volume :
- 13
- Issue :
- 7
- Database :
- Directory of Open Access Journals
- Journal :
- Journal of Comparative Effectiveness Research
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.0f9a26f8ed0f478b991cca3b3481423d
- Document Type :
- article
- Full Text :
- https://doi.org/10.57264/cer-2023-0158