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Six-minute walk test as clinical end point in cardiomyopathy clinical trials, including ATTR-CM: a systematic literature review

Authors :
Jose Nativi-Nicolau
Ali Yilmaz
Noel Dasgupta
Richard Macey
James Cochrane
Judith Peatman
Catherine Summers
Jennifer Luth
Ronald Zolty
Source :
Journal of Comparative Effectiveness Research, Vol 13, Iss 7 (2024)
Publication Year :
2024
Publisher :
Becaris Publishing Limited, 2024.

Abstract

Aim: The six-minute walk test (6MWT) is a common measure of functional capacity in patients with heart failure (HF). Primary clinical study end points in cardiomyopathy (CM) trials, including transthyretin-mediated amyloidosis with CM (ATTR-CM), are often limited to hospitalization and mortality. Objective: To investigate the relationship between the 6MWT and hospitalization or mortality in CM, including ATTR-CM. Method: A PRISMA-guided systematic literature review was conducted using search terms for CM, 6MWT, hospitalization and mortality. Results: Forty-one studies were identified that reported 6MWT data and hospitalization or mortality data for patients with CM. The data suggest that a greater 6MWT distance is associated with a reduced risk of hospitalization or mortality in CM. Conclusion: The 6MWT is an accepted alternative end point in CM trials, including ATTR-CM.

Details

Language :
English
ISSN :
20426313
Volume :
13
Issue :
7
Database :
Directory of Open Access Journals
Journal :
Journal of Comparative Effectiveness Research
Publication Type :
Academic Journal
Accession number :
edsdoj.0f9a26f8ed0f478b991cca3b3481423d
Document Type :
article
Full Text :
https://doi.org/10.57264/cer-2023-0158