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Potential therapeutic target for polysaccharide inhibition of colon cancer progression

Authors :
Jiawei Fan
Jianshu Zhu
He Zhu
Yinmeng Zhang
Hong Xu
Source :
Frontiers in Medicine, Vol 10 (2024)
Publication Year :
2024
Publisher :
Frontiers Media S.A., 2024.

Abstract

In recent years, colon cancer has become one of the most common malignant tumors worldwide, posing a great threat to human health. Studies have shown that natural polysaccharides have rich biological activities and medicinal value, such as anti-inflammatory, anti-cancer, anti-oxidation, and immune-enhancing effects, especially with potential anti-colon cancer mechanisms. Natural polysaccharides can not only protect and enhance the homeostasis of the intestinal environment but also exert a direct inhibition effect on cancer cells, making it a promising strategy for treating colon cancer. Preliminary clinical experiments have demonstrated that oral administration of low and high doses of citrus pectin polysaccharides can reduce tumor volume in mice by 38% (p

Details

Language :
English
ISSN :
2296858X
Volume :
10
Database :
Directory of Open Access Journals
Journal :
Frontiers in Medicine
Publication Type :
Academic Journal
Accession number :
edsdoj.102c7911a6354390ba76f7eed1c7c86a
Document Type :
article
Full Text :
https://doi.org/10.3389/fmed.2023.1325491