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A predicted model-aided reconstruction algorithm for X-ray free-electron laser single-particle imaging
- Source :
- IUCrJ, Vol 11, Iss 4, Pp 602-619 (2024)
- Publication Year :
- 2024
- Publisher :
- International Union of Crystallography, 2024.
-
Abstract
- Ultra-intense, ultra-fast X-ray free-electron lasers (XFELs) enable the imaging of single protein molecules under ambient temperature and pressure. A crucial aspect of structure reconstruction involves determining the relative orientations of each diffraction pattern and recovering the missing phase information. In this paper, we introduce a predicted model-aided algorithm for orientation determination and phase retrieval, which has been tested on various simulated datasets and has shown significant improvements in the success rate, accuracy and efficiency of XFEL data reconstruction.
Details
- Language :
- English
- ISSN :
- 20522525
- Volume :
- 11
- Issue :
- 4
- Database :
- Directory of Open Access Journals
- Journal :
- IUCrJ
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.108ff757f1fa4743a415c9e054f2914a
- Document Type :
- article
- Full Text :
- https://doi.org/10.1107/S2052252524004858