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Abnormal degradation of the neuronal stress-protective transcription factor HSF1 in Huntington’s disease
- Source :
- Nature Communications, Vol 8, Iss 1, Pp 1-17 (2017)
- Publication Year :
- 2017
- Publisher :
- Nature Portfolio, 2017.
-
Abstract
- Huntington’s disease (HD) is caused by misfolding of mutant Htt protein. The authors find that in HD models, the decreased expression of heat shock transcription factor 1 that usually protects against protein misfolding, is in part caused by elevated CK2α’ kinase and Fbxw7 E3 ligase expression.
- Subjects :
- Science
Subjects
Details
- Language :
- English
- ISSN :
- 20411723
- Volume :
- 8
- Issue :
- 1
- Database :
- Directory of Open Access Journals
- Journal :
- Nature Communications
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.10e213fe581949ff9cd3a516b23f2861
- Document Type :
- article
- Full Text :
- https://doi.org/10.1038/ncomms14405