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Significance of immunophenotypic, cytogenetic, and molecular markers in adult patients with T-cell lymphoblastic leukemia

Authors :
A. N. Vasileva
O. A. Aleshina
E. S. Kotova
B. V. Biderman
T. N. Obukhova
I. V. Galtseva
V. N. Dvirnyk
E. I. Zakharko
A. B. Sudarikov
E. N. Parovichnikova
Source :
Онкогематология, Vol 19, Iss 2, Pp 14-25 (2024)
Publication Year :
2024
Publisher :
ABV-press, 2024.

Abstract

Background. Current chemotherapy protocols for T-cell acute lymphoblastic leukemia (T-ALL) allow achieving a 5-year overall survival of 60–90 %, but relapsed and refractory forms remain incurable situations.Aim. To determine the significance of immunophenotypic, cytogenetic and molecular markers in adult T-ALL patients receiving therapy according to the ALL-2016 protocol.Materials and methods. From December 2016 to June 2022, 113 patients with primary T-ALL were included in the study. Cytogenetic study was performed in 104 (92 %) patients; anomalies in the IKZF1 and NOTCH1 genes were investigated in 43 (38 %) patients.Results. The worst prognosis was in patients with ETP and near-ETP variants of T-ALL (3-year disease-free survival was 54 % in ETP group, 33 % in near-ETP group vs TI/II – 79 %, TIII – 89 %, TIV – 75 %). In early T-ALL variants, abnormal karyotype was most common (ETP – 80.7 %, near-ETP – 60 %). Aberrations in NOTCH1 gene were found in 53 % of cases (in 23 out of 43 patients), and no mutations were found in IKZF1 gene in our study. In the group with no NOTCH1 abnormalities, the overall survival was significantly worse than in the group with abnormalities (NOTCH1– – 52 % vs NOTCH1+ –81 %; p = 0.05).

Details

Language :
Russian
ISSN :
18188346 and 24134023
Volume :
19
Issue :
2
Database :
Directory of Open Access Journals
Journal :
Онкогематология
Publication Type :
Academic Journal
Accession number :
edsdoj.1175d824e51baec49dd4a48c0c7
Document Type :
article
Full Text :
https://doi.org/10.17650/1818-8346-2024-19-2-14-25