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Multi-modal profiling of human fetal liver hematopoietic stem cells reveals the molecular signature of engraftment

Authors :
Kim Vanuytsel
Carlos Villacorta-Martin
Jonathan Lindstrom-Vautrin
Zhe Wang
Wilfredo F. Garcia-Beltran
Vladimir Vrbanac
Dylan Parsons
Evan C. Lam
Taylor M. Matte
Todd W. Dowrey
Sara S. Kumar
Mengze Li
Feiya Wang
Anthony K. Yeung
Gustavo Mostoslavsky
Ruben Dries
Joshua D. Campbell
Anna C. Belkina
Alejandro B. Balazs
George J. Murphy
Source :
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
Publication Year :
2022
Publisher :
Nature Portfolio, 2022.

Abstract

During human embryonic development, haematopoietic stem cells of the foetal liver undergo expansion, while retaining engraftment capacity. Here the authors apply CITE-seq to profile single cells from a human foetal liver, identifying a molecular signature of engraftment potential

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723
Volume :
13
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.11a57fa10405ca22f6fddb6df2365
Document Type :
article
Full Text :
https://doi.org/10.1038/s41467-022-28616-x