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Dengue Fever Surveillance in Mato Grosso do Sul: Insights from Genomic Analysis and Implications for Public Health Strategies

Authors :
Larissa Domingues Castilho de Arruda
Marta Giovanetti
Vagner Fonseca
Marina Castilhos Souza Umaki Zardin
Gislene Garcia de Castro Lichs
Silvia Asato
Ana Olivia Pascoto Esposito
Miriam Tokeshi Müller
Joilson Xavier
Hegger Fritsch
Mauricio Lima
Carla de Oliveira
Elaine Vieira Santos
Livia de Mello Almeida Maziero
Danila Fernanda Rodrigues Frias
Danielle Ahad das Neves
Liliane Ferreira da Silva
Ellen Caroline Rodrigues Barretos
Paulo Eduardo Tsuha Oshiro
Bianca Modafari Goday
Jéssica Klener Lemos dos Santos
Simone Kashima
Carlos F. C. de Albuquerque
Rodrigo Fabiano do Carmo Said
Alexander Rosewell
Luiz Henrique Ferraz Demarchi
Julio Croda
Luiz Carlos Junior Alcantara
Crhistinne Cavalheiro Maymone Gonçalves
Source :
Viruses, Vol 15, Iss 9, p 1790 (2023)
Publication Year :
2023
Publisher :
MDPI AG, 2023.

Abstract

Since its discovery in early 1916, dengue fever, a common vector-borne illness in Brazil, has resulted in extensive urban outbreaks and poses a serious threat to the public’s health. Understanding the dynamics of Dengue Virus (DENV) serotypes circulating in different regions of Brazil is essential for implementing effective disease control and prevention measures. In response to this urgent need, we conducted an on-site training program in genomic surveillance in collaboration with the Central Laboratory of Health and the Secretary of Health of the Mato Grosso do Sul state. This initiative resulted in the generation of 177 DENV genome sequences collected between May 2021 and May 2022, a period during which over 11,391 dengue fever cases were reported in the state. Through this approach, we were able to identify the co-circulation of two different dengue serotypes (DENV1 and DENV2) as well as the existence of diverse viral lineages within each genotype, suggesting that multiple introduction events of different viral strains occurred in the region. By integrating epidemiological data, our findings unveiled temporal fluctuations in the relative abundance of different serotypes throughout various epidemic seasons, highlighting the complex and changing dynamics of DENV transmission throughout time. These findings demonstrate the value of ongoing surveillance activities in tracking viral transmission patterns, monitoring viral evolution, and informing public health actions.

Details

Language :
English
ISSN :
19994915
Volume :
15
Issue :
9
Database :
Directory of Open Access Journals
Journal :
Viruses
Publication Type :
Academic Journal
Accession number :
edsdoj.11db2c9acfaf460ca220e14db2c33615
Document Type :
article
Full Text :
https://doi.org/10.3390/v15091790