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Thin-layer Chromatography–Nuclear Magnetic Resonance Spectroscopy – A Versatile Tool for Pharmaceutical and Natural Products Analysis
- Source :
- CHIMIA, Vol 66, Iss 5 (2012)
- Publication Year :
- 2012
- Publisher :
- Swiss Chemical Society, 2012.
-
Abstract
- Thin-layer chromatography (TLC) is a mature and very established technique, frequently used in many fields of applications ranging from natural product analysis to chemical or pharmaceutical applications. The introduction of a commercially available TLC–MS interface was a major step complementing the ease of use of TLC with structural elucidation power of mass spectrometry (MS). The TLC-MS interface simplifies the workflow dramatically to gain structural information directly from TLC separations. This article describes the potential of TLC-nuclear magnetic resonance spectroscopy (NMR) utilizing the TLC-MS interface to straightforwardly characterize zones of interest by NMR spectroscopy with a focus on quantification of active pharmaceutical ingredients (API) in formulations and identification of active principles in plant extracts.
Details
- Language :
- German, English, French
- ISSN :
- 00094293 and 26732424
- Volume :
- 66
- Issue :
- 5
- Database :
- Directory of Open Access Journals
- Journal :
- CHIMIA
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.11e3d8e29bef4fcba73b5cd59bcf79fa
- Document Type :
- article
- Full Text :
- https://doi.org/10.2533/chimia.2012.347