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Selenium, TGF-Beta and Infectious Endemic Cardiopathy: Lessons from Benchwork to Clinical Application in Chagas Disease

Authors :
Tania C. Araujo-Jorge
Maria Teresa Rivera
Jean Vanderpas
Luciana R. Garzoni
Anna Cristina C. Carvalho
Mariana C. Waghabi
Marcelo T. Holanda
Mauro F. F. Mediano
Alejandro M. Hasslocher-Moreno
Maria da Gloria Bonecini-Almeida
Roberto M. Saraiva
Roberto R. Ferreira
Source :
Biomolecules, Vol 12, Iss 3, p 349 (2022)
Publication Year :
2022
Publisher :
MDPI AG, 2022.

Abstract

For over 60 years, selenium (Se) has been known as an essential microelement to many biological functions, including cardiovascular homeostasis. This review presents a compilation of studies conducted in the past 20 years related to chronic Chagas disease cardiomyopathy (CCC), caused by Trypanosoma cruzi infection, a neglected disease that represents a global burden, especially in Latin America. Experimental and clinical data indicate that Se may be used as a complementary therapy to prevent heart failure and improve heart function. Starting from the main questions “Is Se deficiency related to heart inflammation and arrhythmogenesis in CCC?” and “Could Se be recommended as a therapeutic strategy for CCC?”, we show evidence implicating the complex and multidetermined CCC physiopathology, discussing its possible interplays with the multifunctional cytokine TGF-β as regulators of immune response and fibrosis. We present two new proposals to face this global public health challenge in vulnerable populations affected by this parasitic disease: fibrosis modulation mediated by TGF-β pathways and the possible use of selenoproteins as antioxidants regulating the increased reactive oxygen stress present in CCC inflammatory environments. We assess the opportunity to consider the beneficial effects of Se in preventing heart failure as a concept to be applied for CCC patients.

Details

Language :
English
ISSN :
2218273X
Volume :
12
Issue :
3
Database :
Directory of Open Access Journals
Journal :
Biomolecules
Publication Type :
Academic Journal
Accession number :
edsdoj.12113741304a7fa3bbefbb8d6b49aa
Document Type :
article
Full Text :
https://doi.org/10.3390/biom12030349