Mechanisms of Intestinal Serotonin Transporter (SERT) Upregulation by TGF-β1 Induced Non-Smad Pathways.

Authors :: Saad Nazir
Anoop Kumar
Ishita Chatterjee
Arivarasu N Anbazhagan
Tarunmeet Gujral
Shubha Priyamvada
Seema Saksena
Waddah A Alrefai
Pradeep K Dudeja
Ravinder K Gill
Source :: PLoS ONE, Vol 10, Iss 5, p e0120447 (2015)
Publication Year :: 2015
Publisher :: Public Library of Science (PLoS), 2015.
Abstract: TGF-β1 is an important multifunctional cytokine with numerous protective effects on intestinal mucosa. The influence of TGF-β1 on serotonin transporter (SERT) activity, the critical mechanism regulating the extracellular availability of serotonin (5-HT), is not known. Current studies were designed to examine acute effects of TGF-β1 on SERT. Model human intestinal Caco-2 cells grown as monolayer's or as cysts in 3D culture and ex vivo mouse model were utilized. Treatment of Caco-2 cells with TGF-β1 (10 ng/ml, 60 min) stimulated SERT activity (~2 fold, P

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