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Mutual inactivation of two RING-finger-type E3 ubiquitin ligases during cell cycle progression
- Source :
- Molecular & Cellular Oncology, Vol 8, Iss 1 (2021)
- Publication Year :
- 2021
- Publisher :
- Taylor & Francis Group, 2021.
-
Abstract
- CRL and APC/C belong to the RING-finger-type E3 ligases, and both play important roles in cell cycle regulation. Recently, we found that SAG, a RING component of CRL, acts as an endogenous inhibitor of APC/C by competing with APC2 for E2s binding; while APC/CCDH1 targets SAG for ubiquitylation and degradation at G1 phase. The negative crosstalk between these two E3s ensures the orderly cell cycle progression.
Details
- Language :
- English
- ISSN :
- 23723556
- Volume :
- 8
- Issue :
- 1
- Database :
- Directory of Open Access Journals
- Journal :
- Molecular & Cellular Oncology
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.12886a56c73043fe90e2c085d2fb6482
- Document Type :
- article
- Full Text :
- https://doi.org/10.1080/23723556.2020.1837582