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Non-peptide compounds from Kronopolites svenhedini (Verhoeff) and their antitumor and iNOS inhibitory activities

Authors :
Yuan-Nan Yuan
Jin-Qiang Li
Hong-Bin Fang
Shao-Jun Xing
Yong-Ming Yan
Yong-Xian Cheng
Source :
Beilstein Journal of Organic Chemistry, Vol 19, Iss 1, Pp 789-799 (2023)
Publication Year :
2023
Publisher :
Beilstein-Institut, 2023.

Abstract

Six new compounds, including a tetralone 1, two xanthones 2 and 3, a flavan derivative 4, and two nor-diterpenoids 7 and 8, accompanied by two known flavan derivatives 5 and 6 and a known olefine acid (9) were isolated from whole bodies of Kronopolites svenhedini (Verhoeff). The structures of the new compounds were determined by 1D and 2D nuclear magnetic resonance (NMR) and other spectroscopic methods, as well as computational methods. Selected compounds were evaluated for their biological properties against a mouse pancreatic cancer cell line and inhibitory effects on iNOS and COX-2 in RAW264.7 cells.

Details

Language :
English
ISSN :
18605397
Volume :
19
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Beilstein Journal of Organic Chemistry
Publication Type :
Academic Journal
Accession number :
edsdoj.12c370a61c3543348e5ae8e883f516ed
Document Type :
article
Full Text :
https://doi.org/10.3762/bjoc.19.59