Back to Search
Start Over
The ABCG2 Q141K hyperuricemia and gout associated variant illuminates the physiology of human urate excretion
- Source :
- Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
- Publication Year :
- 2020
- Publisher :
- Nature Portfolio, 2020.
-
Abstract
- The common ABCG2 variant Q141K contributes to hyperuricemia and gout risk. Here, using a human interventional study and a new orthologous mouse model, the authors report a tissue specific pathobiology of the Q141K variant, and support a significant role for ABCG2 in urate excretion in both the kidney and intestine.
- Subjects :
- Science
Subjects
Details
- Language :
- English
- ISSN :
- 20411723 and 63333244
- Volume :
- 11
- Issue :
- 1
- Database :
- Directory of Open Access Journals
- Journal :
- Nature Communications
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.12c73f6333324432b9f2c84850631506
- Document Type :
- article
- Full Text :
- https://doi.org/10.1038/s41467-020-16525-w