Comprehensive Analysis of Potential Correlation Between Solute Carrier 1A (SLC1A) Family and Lung Adenocarcinoma

Xiaowu Zhong,1– 3,* Lihua Yao,1,2,* Lei Xu,3,* Qiang Ma,1,2 Guangcheng Huang,1,2 Miyuan Yang,2 Chuanli Gao,2 Jibing Cheng,1,2 Xi Zhou,2 Qinrong Li,2 Xiaolan Guo1– 3 1Department of Clinical Laboratory, Affiliated Hospital of North Sichuan Medical College, Nanchong, 637000, People’s Republic of China; 2Department of Laboratory Medicine, North Sichuan Medical College, Nanchong, 637000, People’s Republic of China; 3Translational Medicine Research Center, North Sichuan Medical College, Nanchong, 637000, People’s Republic of China*These authors contributed equally to this workCorrespondence: Xiaolan Guo, Department of Clinical Laboratory, Affiliated Hospital of North Sichuan Medical College, Nanchong, 637000, People’s Republic of China, Tel +86-817-2282059, Fax +86-817-2282059, Email alan5200@hotmail.comBackground: Lung adenocarcinoma (LUAD) is the most common dangerous malignant tumor and the leading cause of global cancer incidence and mortality. The Solute Carrier 1A (SLC1A) family play a significant part in cellular biological process, inflammation, and immunity. Specific functions of the SLC1A family in lung cancer are still not systematically described.Objective: This study aimed to explore the best biological understanding of SLC1A family in lung cancer.Methods: To study the expression and role of the SLC1A family in lung cancer, researchers used a variety of bioinformatics databases and tools.Results: Aberrant expression of SLC1A family genes were demonstrated and analyzed the association with gender, tumor grade, cancer stages, and nodal metastasis status. The ectopic expression of SLC1A family genes has prognostic value for LUAD patients. Immune infiltration revealed a significant correlation between SLC1A family genes expression in LUAD. SLC1A family genes were involved in manifold biological processes and have different levels of DNA methylation and genetic alteration.Conclusions: These findings suggested that members of the SLC1A family could be a potential target for the development of LUAD therapeutics as well as a reliable indicator of LUAD prognostic value.Graphical Abstract: Keywords: lung adenocarcinoma, SLC1A family, expression, prognosis, bioinformatics analysis