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Hexane Extract from Tradescantia pallida (Rose) D.R. Hunt (Commelinaceae): Its Volatile Constituents and in vitro Antifungal and Cytotoxic Activities
- Source :
- Brazilian Archives of Biology and Technology, Vol 65 (2022)
- Publication Year :
- 2022
- Publisher :
- Instituto de Tecnologia do Paraná (Tecpar), 2022.
-
Abstract
- Abstract: Tradescantia pallida (Commelinaceae) has shown promising antibacterial, antioxidant and anticancer activities. This study aimed at extracting hexane from T. pallida (HE-TP) aerial parts to identify and quantify its volatile compounds by GC-MS and GC-FID and at evaluating its antifungal and antiproliferative activities. (E)-4-Methoxycynnamic acid (50.2%), 2,5-di-tert-butyl-1,4-benzoquinone (13.7%) and epijuvabione (10.4%) were the major components identified in HE-TP. HE-TP was incorporated into PDA medium, poured into Petri dishes and transferred to mycelial discs of pathogens. Percentages of inhibition of fungal growth were determined. HE-TP showed remarkable antifungal potential at the dose of 400 µL since it inhibited 100% of Penicillium digitatum and Sclerotinia sclerotiorum growth and 92.6% of Rhizopus stolonifer growth. Besides, HE-TP demonstrated cytotoxic activity against different human tumor cell lines with IC50 values between 231.43 and 428.76 µg/mL. Therefore, results showed that HE-TP has potential against fungi of agronomic interest and tumor cells.
Details
- Language :
- English
- ISSN :
- 16784324
- Volume :
- 65
- Database :
- Directory of Open Access Journals
- Journal :
- Brazilian Archives of Biology and Technology
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.138acad3cb44ab097f041767931a91b
- Document Type :
- article
- Full Text :
- https://doi.org/10.1590/1678-4324-2022210621