Potency of mycotoxin binders on MDA level, expressions of caspase 9 and caspase 3 in the uterus of mice exposed to zearalenone

This study examined effect of mycotoxin binder administered to female mice exposed to zearalenon on apoptosis incidence by observe at MDA, Caspase 9 and 3 levels in mice uterus. Negative control group (K) was not exposed to zearalenon and without the administration of mycotoxin binders, positive control group (K) exposed to zearalenon of 0.1 mg/head/day and without the provision of mycotoxin binders; and treatment groups (P1, P2, P3) were exposed to zearalenon 0.1 mg/head/day by providing mycotoxin binders each 0.5; 1; 2 mg/head/day. Zearalenon and mycotoxinbinders administration was conducted for 10 days. Results on MDA level were as follows 15.48  0.50 (K), 45.59  0.50 (K+), 34.92  3.38 (P1), 27.72  1.25 and 23.89  3.74. Caspase 9 levels showed the following results: 0.3  0.60 (K), 8.3  0.90 (K), 3.6  0.41 (P1), 3.3  0.34 (P2) and 2.8  0.28 (P3), while the levels of Caspase3 were as follows: 3.35  0.44 (K),12.5  0.66 (K), 3.6  0.41 (P1), 4.80  0.43 (P2) and 3.85  0.50 (P3). In conclusion, mycotoxin binders may lower malondialdehyde (MDA) level and the expression of caspase 9 and caspase3 in the uterus of mice exposed to zearalenon