Research progress in the relationship between EPIYA motif and Helicobacter pylori infection-associated gastropathy

Helicobacter pylori （Hp） is a major human pathogen. Hp infection will cause a series of gastrointestinal diseases， such as chronic gastritis， peptic ulcer and gastric cancer， etc. In recent years， with the increasing incidence of these diseases， their etiology and pathogenesis have attracted more and more attention from many scholars around the world. The pathogenic mechanism of cytotoxin-associated gene A （CagA）， one of the virulence genes of Hp， has captivated widespread attention. EPIYA motif and Hp infection-associated gastropathy have become a hot topic. In this article， the relationship between EPIYA motif and gastropathy related to Hp infection was briefly reviewed.